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Here are some other symptoms: Iron-deficiency anemia symptoms may be mild, but as the condition advances, they can get worse and include: Extreme fatigue Weakness Pale skin Chest pain, rapid heartbeat, or shortness of breath Headache, dizziness, or light-headedness Cold hands and feet An inflamed or sore tongue Brittle nails Odd cravings for ice, dirt, or starch Loss of appetite, most often in babies and kids Aplastic anemia symptoms may be severe from the start or gradually worsen over time

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When someone has an MTHFR mutation it handicaps the efficiency of the methylation cycle by up to 90%